WFI System

Multi-Effect Distillatiller – Turnback Multi-Effect Distillation Systems for Water for Injection Production

We design, manufacture, and validate multi-effect distillation stills for the production of Water for Injection. Our MED systems are the most energy-efficient method to generate pyrogen-free, sterile WFI for pharmaceutical and biotech applications.

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What Is a Multi-Effect Distillatiller

A multi-effect distillation still is a thermal device that produces Water for Injection by evaporating purified water and condensing the resulting vapor. The term multi-effect refers to the use of multiple evaporators in series, where the vapor from one effect heats the next. This design significantly reduces energy consumption compared to single-effect stills.

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How Our Multi-Effect Distillation Still Works

First Effect

· Purified water feed enters the first evaporator

· Industrial steam or electric heating provides initial energy

· Pure vapor is generated

Subsequent Effects

· Vapor from the first effect heats the second effect

· More pure vapor is generated without additional steam input

· Process repeats across 3 to 8 effects depending on capacity

· Each effect reuses energy from the previous effect

Final Condensation

· Cooling water condenses the pure vapor

· Distillate is collected as Water for Injection

· Pyrogens and impurities remain in the reject stream

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Key Features of Our Multi-Effect Distillatiller

· Falling film evaporator design for high heat transfer efficiency

· 316L stainless steel construction, electropolished internal surfaces

· Automatic pyrogen shedding during start-up

· Continuous conductivity and temperature monitoring

· Low energy consumption – as low as 0.1 to 0.15 kilowatt-hours per liter

· Compact vertical or horizontal configuration

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Performance Standards

Our multi-effect distillation stills are designed to meet:

· USP and EP monographs for Water for Injection

· ISPE Baseline Guide for Water and Steam

· ASME BPE for sanitary piping and components

· 21 CFR Part 11 for electronic records

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Typical Applications

· Water for Injection generation for parenteral drug manufacturing

· Feed water for pure steam generators

· Final rinse for sterile containers and closures

· Buffer and media preparation for biologics

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Capacity Range

We provide multi-effect distillation stills for:

· Small scale: 100 to 500 liters per hour for laboratory or pilot use

· Medium scale: 500 to 3,000 liters per hour for production facilities

· Large scale: 3,000 to 10,000 liters per hour for large pharmaceutical plants

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Our Multi-Effect Distillatiller Delivery

We manage your WFI generation system from start to finish:

· Capacity and load analysis

· Still selection and skid fabrication

· Integration with purified water feed and storage loop

· Factory acceptance testing with performance verification

· On-site installation and commissioning

· Performance qualification including pyrogen testing

· Full documentation package for regulatory submission

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Why Choose Our Multi-Effect Distillation Still

· Single point of responsibility for the complete WFI generation system

· Energy-efficient operation reduces long-term operating costs

· Reliable pyrogen-free distillate with automatic monitoring

· Compact footprint saves valuable cleanroom space

· Fully validated system ready for regulatory inspection

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Conclusion

Our turnkey multi-effect distillation stills deliver energy-efficient, compliant, and pyrogen-free Water for Injection – from purified water feed to final storage tank. We provide a complete solution under one contract.